Endocrine Abstracts

Background: Recent studies have demonstrated antioxidant and anti-inflammatory properties of metformin and vildagliptin, that could result in some positive effects on kidney function in diabetes. Indeed, in our previous study vildagliptin attenuated routine renal dysfunction markers in insulinopenic diabetic rats, however metformin didn’t improve it. In our current study we evaluated not only glomerular dysfunction marker (albuminuria), but also novel markers of proximal ...

Non-genetic animal models of diabetic nephropathy (DN) are most commonly reproduced by using streptozotocin (STZ) which preferentially gets into β-cells via GLUT2 transporters. However, STZ administration results in nephrotoxic effects as well, due to expression of GLUT2 by renal tubular epithelial cells. We hypothesized that nicotinamide (NA), which is considered to attenuate the severity of STZ-induced β-cell damage, could also prevent tubular alteration. Starting ...